Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli
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چکیده
منابع مشابه
Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli
BACKGROUND As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal metalloproteinase activities are related to numerous diseases such as arthritis, cancer, atherosclerosis, and ...
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ژورنال
عنوان ژورنال: Microbial Cell Factories
سال: 2017
ISSN: 1475-2859
DOI: 10.1186/s12934-017-0686-9